It can also cause haematological effects and nephrotoxicity.

It can also cause haematological effects and nephrotoxicity.

Endosulfan causes neurotoxicity and haematological effects and nephrotoxicity.

Endosulfan causes neurotoxicity, haematological effects and nephrotoxicity but shows no carcinogenic or mutagenic properties.

Observed effects were among others: decreases in the mean body weights of male rats at exposure levels ≥ 1 000 mg/kg diet and in females at all concentrations (≥ 33 mg/kg), increase in absolute and relative liver weights (33 mg/kg in males), centrilobular hepatocellular hypertrophy (as low as 330 mg/kg for males), increases in kidney weights and renal histopathological effects at concentrations as low as 100 mg/kg, nephrotoxic effects in females (≥ 1 000 mg/kg), increase of the concentration of protein in the urine in male and female rats at ≥ 1 000 mg/kg, decrease of free thyroxin and total thyroxin concentrations in male and female rats indicating moderate hypothyroxinemia and abnormalities were observed at concentrations of ≥330 mg/kg in females and ≥ 1 000 mg/kg in males.